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SML2978

d9A-2

≥98% (HPLC)

Synonym(s):

N-(14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-yl)-4′-fluoro-3′-methyl-2-[4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl]-[1,1′-biphenyl]-4-carboxamide

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Size/SKUAvailabilityPrice
5 mg
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$92.10
25 mg
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$371.00

About This Item

Empirical Formula (Hill Notation):
C46H54FN7O9
CAS Number:
Molecular Weight:
867.96
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$92.10


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CCC1N2C(C(C=CC=C3NCCOCCOCCOCCOCCNC(C4=CC(N5CCC(C6=C(C)N=CN6)CC5)=C(C7=CC=C(F)C(C)=C7)C=C4)=O)=C3C2=O)=O)NC1=O

InChI key

WMBSSRAFHKGIRA-UHFFFAOYSA-N

Biochem/physiol Actions

d9A-2 is a potent degrader (PROTAC) of the solute carrier SLC9A1 impairs recovery from acid load and is potently cytotoxic to multiple cancer cell lines. Also, d9A-2 incites degradation of some SLC9 members including closely related SLC9A2 and SLC9A4, distant SLC9A7 and SLC9B1. d9A-2 comprise w9A ligand binding to SLC9A1 and the phthalimide-based CRBN binder.
potent degrader (PROTAC) of the solute carrier SLC9A1

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This Item
SML3245SML3178SML3053
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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