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SML2986

NSC 15520

≥98% (HPLC)

Synonym(s):

15-Carboxy-13-isopropylatis-13-ene-17,18-dioic acid, NSC15520

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$144.00
25 mg

Available to ship TODAYfromMILWAUKEE

$461.00

About This Item

Empirical Formula (Hill Notation):
C24H34O6
CAS Number:
730960-98-2
Molecular Weight:
418.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02634528
Assay:
≥98% (HPLC)
Form:
powder

$144.00

Available to ship TODAYDetails

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[P](=O)(OCC\C(=C(/N(Cc2c(nc(nc2)C)N)C=O)\C)\SC(=O)c1ccccc1)(O)O

InChI

1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+

InChI key

BTNNPSLJPBRMLZ-GHRIWEEISA-N

Biochem/physiol Actions

Inhibitor of the RPA70 N-terminal protein interaction domain
NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9.

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This Item
492493705616491578
NSC 15520 ≥98% (HPLC)

Sigma-Aldrich

SML2986

NSC 15520

DL-Pipecolinic acid-(carboxy-13C) 99 atom % 13C

Sigma-Aldrich

492493

DL-Pipecolinic acid-(carboxy-13C)

3-Methyluric acid-2,4,5,6-13C4, 1,3,9-15N3 ≥98 atom %, ≥98% (CP)

Sigma-Aldrich

705616

3-Methyluric acid-2,4,5,6-13C4, 1,3,9-15N3

4-Methoxybenzoic acid-α-13C 99 atom % 13C

Sigma-Aldrich

491578

4-Methoxybenzoic acid-α-13C

description

≥98% (HPLC)

description

99 atom % 13C

description

≥98 atom %, ≥98% (CP)

description

99 atom % 13C

assay

≥98% (HPLC)

assay

-

assay

≥98% (CP)

assay

99% (CP)

form

powder

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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