Skip to Content
MilliporeSigma

Skip To

SML2989

OSMI-2

≥98% (HPLC)

Synonym(s):

(R)-Methyl 2-(2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamido)acetate, OSMI 2, OSMI2

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$196.00
25 mg

Available to ship TODAYfromMILWAUKEE

$602.00

About This Item

Empirical Formula (Hill Notation):
C26H25N3O7S2
CAS Number:
Molecular Weight:
555.62
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$196.00


Available to ship TODAYDetails


​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -175.0 to -135.0°, c = 1.0 in chloroform-d

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1)C=CC2=C1C=CC(S(N[C@@H](C(N(CC3=CC=CS3)CC(OC)=O)=O)C4=C(C=CC=C4)OC)(=O)=O)=C2

Biochem/physiol Actions

Cell-permeable precursor of an active-site O-GlcNAc transferase (OGT) inhibitor that effectively downregulates cellular protein O-GlcNAc level.
OSMI-2 is a cell-permeable precursor of an active site-targeting (Kd = 140 nM) O-GlcNAc transferase (OGT) inhibitor. Upon cell entry, OSMI-2 is activated by cellular esterase to the active inhibitor that effectively downregulates cellular protein O-GlcNAc level (20-40 μM for 4 h/HCT116, 50 μM for 24 h/HEK293T) and renders LNCaP prostate cancer cells dependent on CDK9 for growth (confluency post 96-hr treatment = 73% with 40 μM OSMI-2, 56% with 0.5 μM AT7519, 19% with co-treatment; control cells at 20% and 81% at 0 and 96 hr, respectively).

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML1621SML2090
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% ruthenium (Ru) basis (elemental analysis)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% ruthenium (Ru) basis (elemental analysis)

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

color

white to beige

color

white to beige

color

faint red to dark brown


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters