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SML2990

dCeMM2

≥98% (HPLC)

Synonym(s):

2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide, N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$104.00
25 mg

Available to ship TODAYfromMILWAUKEE

$420.00

About This Item

Empirical Formula (Hill Notation):
C16H11ClN6OS
CAS Number:
Molecular Weight:
370.82
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$104.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=NC=C(Cl)C=C1)CSC2=NC3=C(C4=C(N3)C=CC=C4)N=N2

InChI

1S/C16H11ClN6OS/c17-9-5-6-12(18-7-9)20-13(24)8-25-16-21-15-14(22-23-16)10-3-1-2-4-11(10)19-15/h1-7H,8H2,(H,18,20,24)(H,19,21,23)

InChI key

VFWVTIHYVUKNGR-UHFFFAOYSA-N

Biochem/physiol Actions

cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase
dCeMM2 is a cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase complex. dCeMM2 induced proximity between CDK12–cyclin K and the CRL complex adaptor protein DDB1 that causes ubiquitination and proteasomal degradation of cyclin K.

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This Item
SML3568SML1336SML2333
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

off-white to blue-gray


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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