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SML2994

HQ461 Hydrobromide

≥98% (HPLC)

Synonym(s):

2-(2-((6-Methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide hydrobromide, 2-[(6-Methyl-2-pyridinyl)amino]-N-(5-methyl-2-thiazolyl)-4-thiazoleacetamide hydrobromide

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$136.00
25 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$545.00

About This Item

Empirical Formula (Hill Notation):
C15H15N5OS2HBr
Molecular Weight:
426.35
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$136.00


Estimated to ship onAugust 17, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

CDK12 kinase domain-targeting molecular glue that impairs CDK12/13 downstream signaling by inducing cyclin K (CycK) ubiquitination and degradation.
HQ461 is a CDK12 kinase domain-targeting molecular glue that promotes CDK12 interaction with DDB, resulting in DDB1-CUL4-RBX1 E3 ubiquitin ligase complex-mediated CDK12-interacting protein cyclin K (CycK) polyubiquitination and degradation (1-10 μM; A549). HQ461 treatment impairs A549 cellular CDK12 and CDK13 downstream signaling events, including RNA pol II C-terminal domain (CTD) Ser2 phosphorylation (1-10 μM) and DNA damage response genes expression (10 μM, 16 hrs).

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This Item
SML3262SML1112SML2333
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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