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SML3004

NMDAR/TRPM4 interface inhibitor C8 dihydrochloride

≥98% (HPLC)

Synonym(s):

C8 dihydrochloride, Compound 8 dihydrochloride, N1-[(3-Bromophenyl)methyl]-N1-ethyl-1,2-ethanediamine dihydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$86.40
25 mg

Available to ship TODAYfromMILWAUKEE

$339.00

About This Item

Empirical Formula (Hill Notation):
C11H17BrN2·2HCl
CAS Number:
Molecular Weight:
330.09
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder or solid
Storage condition:
desiccated

$86.40


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Quality Segment

assay

≥98% (HPLC)

form

powder or solid

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

NCCN(CC)CC1=CC=CC(Br)=C1.Cl.Cl

InChI

1S/C11H17BrN2.2ClH/c1-2-14(7-6-13)9-10-4-3-5-11(12)8-10;;/h3-5,8H,2,6-7,9,13H2,1H3;2*1H

InChI key

AQDSZKTVQVSVNC-UHFFFAOYSA-N

Biochem/physiol Actions

Compound 8 (C8) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C8 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 2.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions. C8 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell (RGC) loss in mice in vivo (40 mg/kg i.p. at -16h, -3h before, 0h, 3h, 24h after MCAO or 20 nmol NMDA/2.0 μL by intravitreal injection).
TRPM4 TwinF domain-targeting NMDAR/TRPM4 interaction blocker that protects against TRPM4-mediated excitotoxicity in vitro and in vivo.

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This Item
SML3005648492SAB2102584
description

≥98% (HPLC)

description

≥98% (HPLC)

description

The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.

description

affinity isolated antibody

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

-

form

powder or solid

form

powder

form

solid

form

buffered aqueous solution

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated

storage condition

-

storage condition

OK to freeze, protect from light

storage condition

-

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 50 mg/mL

solubility

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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