Skip to Content
MilliporeSigma

Skip To

SML3005

NMDAR/TRPM4 interface inhibitor C19 dihydrochloride

≥98% (HPLC)

Synonym(s):

2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride, C19 dihydrochloride, Compound 19 dihydrochloride, N-(2,4,5-Trichlorophenyl)-3-aminomethyl-1-pyrrolidineacetamide dihydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$70.60
25 mg

Estimated to ship onSeptember 08, 2026fromMILWAUKEE

$288.00

About This Item

Empirical Formula (Hill Notation):
C13H16Cl3N3O·2HCl
CAS Number:
Molecular Weight:
409.57
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$70.60


Estimated to ship onSeptember 08, 2026Details


Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(CN1CC(CC1)CN)NC2=CC(Cl)=C(C=C2Cl)Cl.Cl.Cl

InChI

1S/C13H16Cl3N3O.2ClH/c14-9-3-11(16)12(4-10(9)15)18-13(20)7-19-2-1-8(5-17)6-19;;/h3-4,8H,1-2,5-7,17H2,(H,18,20);2*1H

InChI key

KKZAEWKBOQYGHO-UHFFFAOYSA-N

Biochem/physiol Actions

Compound 19 (C19) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C19 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 1.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions.
TRPM4 TwinF domain-targeting NMDAR/TRPM4 interaction blocker that protects against TRPM4-mediated excitotoxicity.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML1138SML0667PZ0365
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters