Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD
A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.
description
United States Pharmacopeia (USP) Reference Standard
form
powder
form
powder
form
solid
form
-
assay
≥98% (HPLC)
assay
95.0-105.0%
assay
≥95% (HPLC)
assay
-
Quality Level
100
Quality Level
200
Quality Level
100
Quality Level
-
storage temp.
2-8°C
storage temp.
-
storage temp.
10-30°C
storage temp.
2-8°C
solubility
DMSO: 2 mg/mL, clear
solubility
-
solubility
DMSO: 25 mg/mL
solubility
-
color
white to beige
color
white to off-white
color
white
color
-
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
