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SML3069

NVP-2

≥98% (HPLC)

Synonym(s):

4-[[[5′-Chloro-2′-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4′-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile, NVP2

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$250.00
25 mg

Available to ship TODAYfromMILWAUKEE

$798.00

About This Item

Empirical Formula (Hill Notation):
C27H37ClN6O2
CAS Number:
Molecular Weight:
513.07
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$250.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

C[C@H](COC)N[C@@H]1CC[C@@H](NC2=NC=C(Cl)C(C3=NC(NCC4(CCOCC4)[N+]#[C-])=CC=C3)=C2)CC1

InChI

1S/C27H37ClN6O2/c1-19(17-35-3)32-20-7-9-21(10-8-20)33-26-15-22(23(28)16-30-26)24-5-4-6-25(34-24)31-18-27(29-2)11-13-36-14-12-27/h4-6,15-16,19-21,32H,7-14,17-18H2,1,3H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1

InChI key

OPMDDHBKBFCAJY-NJDAHSKKSA-N

Biochem/physiol Actions

ATP-competitive, highly potent and selective cyclin-dependent kinase CDK9 inhibitor.
NVP-2 is an ATP-competitive, highly potent and selective cyclin-dependent kinase CDK9 inhibitor (human Cdk9/CycT1 IC50 = 0.3 nM with 6 μM ATP; DYRK1B IC50 = 350 nM; CDK7 IC50 >10 ?M; 0-63% inhibition of 366 other kinases at 1 μM, including CDK2/3/4/5/8). NVP-2 inhibits RNA Pol II-mediated transcription by blocking Cdk9-dependent RNA Pol II CTD phosphorylation (250 nM for 1-24 hrs; MOLT4 cells), displaying higher apoptosis-inducing and antiproliferation efficacy than the CDK2/7/9 inhibitor SNS-032 (BMS-387032) in leukemia cultures (MOLT4 IC50 = 9 nM/NVP-2 vs. 173 nM/SNS-032).

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This Item
SML3458SML1680SML2192
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to brown

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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