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SML3085

Evacetrapib

≥95% (HPLC)

Synonym(s):

LY 2484595, LY-2484595, LY2484595, trans-4-({(5S)-5-[{[3,5-bis(Trifluoromethyl)phenyl]methyl}(2-methyl-2H-tetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzazepin-1-yl}methyl)cyclohexanecarboxylic acid, trans-4-[[(5S)-5-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid

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Pack SizeSKUAvailabilityPrice
10 mg
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$123.00
50 mg
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$496.00

About This Item

Empirical Formula (Hill Notation):
C31H36F6N6O2
CAS Number:
1186486-62-3
Molecular Weight:
638.65
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD23105886
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC1=C2C([C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=NN(C)N=N4)CCCN2C[C@H]5CC[C@H](C(O)=O)CC5)=CC(C)=C1

InChI

1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20?,22?,26-/m0/s1

InChI key

IHIUGIVXARLYHP-UXNJHFGPSA-N

Biochem/physiol Actions

Evacetrapib (LY2484595) is an orally active, potent and selective cholesteryl ester transfer protein (CETP) inhibitor (human recombinant CETP IC50 = 5.5 nM). Evacetrapib inhibits CETP activtiy in human plasma ex vivo (IC50 = 36 nM) and in human CETP/ApoAI transgenic mice in vivo (129.7% HDL-C increase 8 h post oral dosing at 30 mg/kg; 98.4%, 98.6%, 18.4% CETP inhibition, respectivley, post 4, 8 and 24 h p.o.). Evacetrapib does not cause the side-effects observed with torcetrapib in cultures (no aldosterone or cortisol synthesis induction in H295R cells) or in vivo (no increase of mean arterial pressure in diabetic fatty rats).
Orally active, potent and selective cholesteryl ester transfer protein (CETP) inhibitor in vitro and in vivo.

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This Item
SML2037SML3018L1920
Evacetrapib ≥95% (HPLC)

Sigma-Aldrich

SML3085

Evacetrapib

SR2595 ≥98% (HPLC)

Sigma-Aldrich

SML2037

SR2595

TH1834 ≥98% (HPLC)

Sigma-Aldrich

SML3018

TH1834

LY255283 ≥98% (HPLC), powder

Sigma-Aldrich

L1920

LY255283

form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

color

white to beige

color

white to faint brown

color

white to beige

color

off-white to light yellow

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000134523
0000134524
0000130192

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Global Trade Item Number

SKUGTIN
SML3085-10MG04065266519983
SML3085-50MG04065266519990

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