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SML3117

N-Desethyl sunitinib hydrochloride

≥98% (HPLC)

Synonym(s):

5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide hydrochloride, N-Desethylsunitinib hydrochloride, N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide hydrochloride, SU 12662 hydrochloride, SU12662 hydrochloride

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Size/SKUAvailabilityPrice
5 mg
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$167.00
25 mg
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$515.00

About This Item

Empirical Formula (Hill Notation):
C20H23FN4O2 · xHCl
CAS Number:
Molecular Weight:
370.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$167.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Fc1cc2c(cc1)NC(=O)\C\2=C/c3[nH]c(c(c3C)C(=O)NCCNCC)C

InChI

1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-

InChI key

LIZNIAKSBJKPQC-GDNBJRDFSA-N

Biochem/physiol Actions

Multi-target tyrosine kinase inhibitor (TKI); major and pharmacologically active metabolite of an anticancer drug sunitinib;
N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor that is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patients, plasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%, respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib.

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This Item
1A050601A050301A05050
description

≥98% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

description

Pharmaceutical Analytical Impurity (PAI)

form

powder

form

solid

form

powder

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-


Pictograms

Health hazardEnvironment

Signal Word

Warning

Hazard Codes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2

Target Organs

blood vessel,Bone marrow

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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