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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $102.00 |
25 mg | Check Cart for Availability | $410.00 |
About This Item
Empirical Formula (Hill Notation):
C20H23N3O2S2
CAS Number:
Molecular Weight:
401.55
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
S=C(NC1=CC=C2SC(C)(CC(C)(C)C2=C1)C)NC(C=C3)=CC=C3[N+]([O-])=O
InChI
1S/C20H23N3O2S2/c1-19(2)12-20(3,4)27-17-10-7-14(11-16(17)19)22-18(26)21-13-5-8-15(9-6-13)23(24)25/h5-11H,12H2,1-4H3,(H2,21,22,26)
InChI key
FWWKIYPMUZVMQG-UHFFFAOYSA-N
Biochem/physiol Actions
Orally available chemopreventive fexible heteroarotinoid (Flex-Het) that induces cancer apoptosis in cultures and in vivo independent of retinoic acid receptor (RAR).
SHetA2 is an orally available chemopreventive fexible heteroarotinoid (Flex-Het) that inhibits cancer growth in cultures (OVCAR-3/SK-OV-3/Caov-3 GI50 = 3.9/4.1/7.0 μM) and in vivo (60-100 mg/kg SiHa xenograft mice) via apoptosis induction independent of retinoic acid receptor (RAR). SHetA2 is reported to bind heatshock proteins HSPA5 (GRP78, BiP), HSPA8 (HSC70, HSP73, HSPA10), HSPA9 (GRP75), resulting in cyclin D1 degradation.
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This Item | |
|---|---|
| description ≥98% (HPLC) | description - |
| assay ≥98% (HPLC) | assay - |
| form powder | form - |
| Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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