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SML3136

CGP-54626

Name: CGP-54626
Brand: SIGMA

≥95% (HPLC), Potent selective GABA(B) receptor antagonist, powder

Synonym(s):

CGP-54626A, Cyclohexylmethyl((S)-3-((S)-1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl)phosphinic acid hydrochloride, P-(Cyclohexylmethyl)-P -[(2S )-3-[[(1S )-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]-phosphinic acid hydrochloride, [3-[N-[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino]-(2S)-hydroxypropyl](cyclohexylmethyl)phosphinic acid hydrochloride, [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₈Cl₂NO₃P · HCl

CAS Number:

149184-21-4

Molecular Weight:

444.76

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD09878291

Assay:

≥95% (HPLC)

Form:

powder

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Properties

Product Name

CGP-54626, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

storage temp.

−20°C

SMILES string

ClC1=C(C=CC([C@@H](NC[C@@H](CP(CC2CCCCC2)(O)=O)O)C)=C1)Cl.Cl

InChI

1S/C18H28Cl2NO3P.ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14;/h7-9,13-14,16,21-22H,2-6,10-12H2,1H3,(H,23,24);1H/t13-,16-;/m0./s1

InChI key

ZQCFHOVIXCJPLE-LINSIKMZSA-N

Description

Biochem/physiol Actions

CGP-54626 is an orally available, potent selective GABAB receptor antagonist with an IC50 of 4 nM that binds to orthosteric site of (Kd = 33.1 nM) GABA(B)-R1. CGP 54626 decreases a sensitivity to ethanol in Drosophila melanogaster model.

Potent selective GABA(B) receptor antagonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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