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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Check Cart for Availability | $136.00 |
About This Item
Empirical Formula (Hill Notation):
C12H20Cl4N2O2
CAS Number:
Molecular Weight:
366.11
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
InChI
1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)
InChI key
FAOMZVDZARKPFJ-UHFFFAOYSA-N
Biochem/physiol Actions
WIN 18,446 is an orally available bisdichloroacetyldiamine that potently inhibits aldehyde dehydrogenase family 1 (ALDH1) members-catalyzed all-trans retinoic acid (atRA) production (IC50 = 88 nM/human testicular S10 fraction, 102 nM/ALDH1A1, 187 nM/ALDH1A3) via retinal oxidation, efficiently inhibits ALDH1A2 enzymatic activity in a time-dependent manner (kinact = 22.0/h, Ki = 1026 nM). The inhibitory activity of WIN 18,446 against atRA production forms the basis of its in vivo efficacy as a male contraceptive in inhibiting spermatogenesis among mulitple mammalian species and zebrafish.
orally available ALDH1A1/ALDH1A2/ALDH1A3 inhibitor with in vivo male contraceptive efficacy by inhibiting spermatogenesis
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description 98% | description ≥95% (HPLC) |
| form powder | form powder | form powder or crystals | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay 98% | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility - | solubility H2O: 10 mg/mL, clear, faintly yellow |
| color white to beige | color white to beige | color - | color - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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