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SML3190

Dehydroevodiamine hydrochloride

≥98% (HPLC)

Synonym(s):

8,14-Dihydro-14-methyl-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one hydrochloride, Dehydroevodiamine chloride, Indolo[2,3:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,14-dihydro-14-methyl-, hydrochloride (1:1)

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$102.00
50 mg

Available to ship TODAYfromMILWAUKEE

$409.00

About This Item

Empirical Formula (Hill Notation):
C19H15N3O · HCl
CAS Number:
Molecular Weight:
337.80
UNSPSC Code:
12352107
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$102.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C1C2=C(C=CC=C2)N(C)C3=C4C(CCN31)=C(C=CC=C5)C5=N4.Cl

InChI

1S/C19H15N3O.ClH/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22;/h2-9H,10-11H2,1H3;1H

InChI key

SVOMSEHNGXLQRU-UHFFFAOYSA-N

Biochem/physiol Actions

Dehydroevodiamine is the major alkaloid of Evodia rutaecarpa that exhibit cardiovascular effects such as bradycardia, hypotension, and vasorelaxation. Dehydroevodiamine potently inhibits hERG channels. Apparently it is a blocker of IKr (rapid delayed rectifier current) with proarrhythmic effects in vitro and in vivo. Dehydroevodiamine ameliorates the spatial memory impairment in the scopolamine-induced amnestic rats. It reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons.
potently inhibits hERG channels; reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons

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This Item
Y0001908PHL89662SMB00235
description

≥98% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

phyproof® Reference Substance

description

≥95% (LC/MS-ELSD)

assay

≥98% (HPLC)

assay

-

assay

≥98.0% (HPLC)

assay

≥95% (LC/MS-ELSD)

form

powder

form

-

form

-

form

solid

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

-

solubility

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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