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SML3193

(S)-GSK2920487A

≥98% (HPLC)

Synonym(s):

(S)-(4-fluorobenzo[b]thiophen-2-yl)(3-(5-methyl-1H-imidazol-1-yl)piperidin-1-yl)methanone, (S)-1, TCMDC-143498

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Size/SKUAvailabilityPrice
5 mg
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$137.00
25 mg
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$556.00

About This Item

Empirical Formula (Hill Notation):
C18H18FN3OS
Molecular Weight:
343.42
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$137.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N1C[C@H](CCC1)N2C=CN=C2C)C3=CC4=C(S3)C=CC=C4F

InChI

1S/C18H18FN3OS/c1-12-20-7-9-22(12)13-4-3-8-21(11-13)18(23)17-10-14-15(19)5-2-6-16(14)24-17/h2,5-7,9-10,13H,3-4,8,11H2,1H3/t13-/m0/s1

InChI key

SBZYUUGJHIROPT-ZDUSSCGKSA-N

Biochem/physiol Actions

(S)-GSK2920487A is a promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani. (S)-GSK2920487A induces the accumulation of the 2,3-oxidosqualene, a substrate of OSC, in promastigotes and cell-free membrane preparations. It is active against axenic and intramacrophage amastigotes. Also, GSK2920487A is active against intracellular T. cruzi.
promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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