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SML3266

AMD070 hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-N′-((1H-benzo[d]imidazol-2-yl)methyl)-N′-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride, AMD 070 hydrochloride, AMD 11070 hydrochloride, AMD-070 hydrochloride, AMD-11070 hydrochloride, AMD11070 hydrochloride, Mavorixafor, N′-(1H-Benzimidazol-2-ylmethyl)-N′-(S)-5,6,7,8-tetrahydro-quinolin-8-yl-butane-1,4-diamine hydrochloride, X4P-001 hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$76.20
25 mg

Available to ship TODAYfromMILWAUKEE

$386.00

About This Item

Empirical Formula (Hill Notation):
C21H27N5 · xHCl
Molecular Weight:
349.47 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD23160058
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$76.20

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NCCCCN([C@@H]1C2=NC=CC=C2CCC1)CC3=NC4=C(C=CC=C4)N3.Cl

InChI

1S/C21H27N5.ClH/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19;/h1-2,6,8-10,13,19H,3-5,7,11-12,14-15,22H2,(H,24,25);1H/t19-;/m0./s1

InChI key

DBNMEMJSDAAGNZ-FYZYNONXSA-N

Biochem/physiol Actions

AMD070 (AMD11070) is an orally active, reversible and selective CXCR4 (CD184, fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) that inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM.
Orally active, reversible and selective CXCR4 (CD184, fusin) antagonist that inhibits HIV-1 replication in host cell cultures.

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AMD070 hydrochloride ≥98% (HPLC)

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Sigma-Aldrich

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description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥90% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear

solubility

H2O: soluble

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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