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SML3274

AZD5904

≥95% (HPLC)

Synonym(s):

(R)-3-(2-Tetrahydrofuryl-methyl)-2-thioxanthine, (R)-TX3, 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one, AZD 5904, AZD-5904, TX3 R-enantiomer, TX4

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$95.80
25 mg

Available to ship TODAYfromMILWAUKEE

$386.00

About This Item

Empirical Formula (Hill Notation):
C10H12N4O2S
CAS Number:
Molecular Weight:
252.29
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder

$95.80


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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1NC(N(C[C@@H]2OCCC2)C3=C1NC=N3)=S

InChI

1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1

InChI key

RSPDBEVKURKEII-ZCFIWIBFSA-N

Biochem/physiol Actions

AZD5904 (TX4) is an orally active 2-thioxanthine class suicide substrate that targets myeloperoxidase (MPO) for mechanism-based inactivation, covalently modifying MPO heme group without converting the enzyme to compound II. AZD5904 effectively inhibits peroxide-induced human MPO chlorination activity (IC50 = 0.2 μM) and extracellular MPO activity in PMA-stimulated human neutrophil cultures (by 68% at 1 μM). Oral administration (20-180 μmol/kg) of the racemate (TX3) is efficacious in reducing inflammation site MPO activity in mice in vivo with 10- to 19-fold selectivity over lactoperoxidase (LPO), thyroid peroxidase (TPO), and >70-fold selectivity over a panel of other enzymes, ion channels, and receptors.
Highly selective and orally available mechanism-based myeloperoxidase (MPO) inactivatior with in vitro and in vivo efficacy.

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This Item
SML2841497401SML2624
description

≥95% (HPLC)

description

≥98% (HPLC)

description

98%

description

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

98%

assay

≥98% (HPLC)

form

powder

form

powder

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

-

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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