Key Documents

t-TUCB

Name: t-TUCB
Brand: SIGMA

≥97% (HPLC), powder, hydrolase (sEH) inhibitor

Synonym(s):

4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid, trans-4-[4-[3-(4-Trifluoromethoxyphenyl)ureido]cyclohexyloxy]benzoic acid, EC 1728, EC-1728, EC1728, UC 1728, UC-1728, UC1728

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₁F₃N₂O₅

CAS Number:

948304-40-3

Molecular Weight:

438.40

MDL number:

MFCD31807631

NACRES:

NA.21

Assay:

≥97% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Description

Application

t-TUCB may be used in in vitro studies to examine lipid accumulation and its interaction with omega-3 epoxides in regulating autophagy and endoplasmic reticulum (ER) stress markers.

Biochem/physiol Actions

t-TUCB is an orally active and potent soluble epoxide hydrolase (sEH) inhibitor (h/m/r IC50 = 0.9/1.3/16 nM). t-TUCB modulates inflammation and autophagy in adipose tissue and liver in obese fat-1 mice (10 μg/mL in drinking water, ∼1.67 mg/kg/d). When administered at 10 mg/kg via s.c. t-TUCB is substantially more effective than t-AUCB and APAU in a diabetic neuropathy model in rats.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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