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SRP0108

HDAC-6 human

recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Synonym(s):

HD6, Histone deacetylase 6, JM21

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50 μg
Usually ships in 2 weeks.
$785.00

About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥80% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected insect cells

$785.00

Usually ships in 2 weeks.
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biological source

human

recombinant

expressed in baculovirus infected insect cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

159 kDa

packaging

pkg of 50 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HDAC6(10013)

General description

HDAC6 (histone deacetylase 6) is a member of the HDAC family of enzyme which are generally linked with gene expression and chromatin dynamics. This protein resides exclusively in the cytoplasm and is present in the perinuclear punctate structures as well as the leading edges of the cell.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

HDAC6 (histone deacetylase 6) functions as a microtubule or tubulin deacetylase, which in turn regulates microtubule-dependent chemotactic cell motility. This protein shows colocalization with p150glued protein, a dynactin component. It contains a ubiquitin binding zinc finger, and interacts with ubiquitinated proteins post-proteasomal inhibition. It is essential for the survival of inflammatory breast cancers (IBCs), though does not function as an oncogene. Treatment of IBC cells with HDAC6 inhibitor ricolinostat (ACY1215) results in the inhibition of IBC cell proliferation both in vitro and in vivo.

Physical form

Formulated in 40 mM Tris-HCl pH8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween20, 3mM DTT, and 20% glycerol.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Other Notes

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.

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HDAC-6 human recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

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Sigma-Aldrich

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Sigma-Aldrich

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Anti-HDAC6 antibody produced in rabbit

Monoclonal Anti-HDAC6 antibody produced in mouse clone 1E2, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

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Monoclonal Anti-HDAC6 antibody produced in mouse

description

recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

description

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

description

affinity isolated antibody

description

clone 1E2, purified immunoglobulin, buffered aqueous solution

Gene Information

human ... HDAC6(10013)

Gene Information

human ... HDAC6(10013)

Gene Information

human ... HDAC6(10013)

Gene Information

human ... HDAC6(10013)

assay

≥80% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

-

assay

-

biological source

human

biological source

human

biological source

rabbit

biological source

mouse

form

aqueous solution

form

aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

recombinant

-

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

Storage Class

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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