This product is not full length. It contains amino acids 1-212 and includes a C-terminal His tag.
SRP0187
Bcl-xL Active human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
Apoptosis regulator Bcl-X, BCL-XL/S, BCL2L1, Bcl-2-like protein 1
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Usually ships in 2 weeks. | $747.00 |
About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
aqueous solution
mol wt
28 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
>0.02 mg/mL
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... BCL2L1(598)
General description
BCL2L1 (B-cell lymphoma 2 like 1) gene codes for the anti-apoptotic protein called Bcl-xL (B-cell lymphoma-extra large) and its isoform Bcl-xS. Bcl-xS functions as an antagonist of Bcl-xL. This gene is localized to human chromosome 20q11.21.
Application
Useful for the study of apoptosis, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions
BCL2L1 (B-cell lymphoma 2 like 1) or Bcl-xS functions as a dominant negative regulator of the anti-apoptotic isoform Bcl-xL. Bcl-xL is involved in modulating anti-apoptotic capacity of chemotherapy-resistant tumors. This protein is highly expressed in michigan cancer foundation 7 (MCF7) human breast carcinoma cells, and studies show that overexpression of Bcl-xS in these MCF-7 cells results in heightened sensitivity to chemotherapy-induced apoptosis by agents such as VP-16 or taxol.
Physical form
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.
Preparation Note
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
1 of 1
This Item | |||
|---|---|---|---|
| description recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | description affinity isolated antibody | description - | description recombinant, expressed in HEK 293 cells |
| assay ≥90% (SDS-PAGE) | assay - | assay - | assay - |
| biological source human | biological source rabbit | biological source rabbit | biological source rabbit |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant expressed in HEK 293 cells |
| form aqueous solution | form buffered aqueous solution | form liquid | form lyophilized |
| Gene Information human ... BCL2L1(598) | Gene Information human ... BCL2L1(598) | Gene Information human ... BCL2L1(598) | Gene Information human ... BCL2L1(598) |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
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Is the BCl-xl full length(233 aa)? or the C-terminal is excluded
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