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SRP0239

EGFR Active human

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

Synonym(s):

ERBB1, Epidermal growth factor receptor, HER1, PIG61, Proto-oncogene c-ErbB-1

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10 μg
Usually ships in 2 weeks.
$560.00

About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
aqueous solution
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected insect cells
Mol wt:
87.3 kDa

$560.00

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biological source

human

recombinant

expressed in baculovirus infected insect cells

assay

≥70% (SDS-PAGE)

form

aqueous solution

potency

≥0.14 units/mg

mol wt

87.3 kDa

packaging

pkg of 10 μg

concentration

>0.02 mg/mL

NCBI accession no.

NM_005228

UniProt accession no.

P00533

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... EGFR(1956)

General description

Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of a family of receptor tyrosine kinases (RTK) called avian erythroblastosis oncogene (BErbB). It contains a ligand-binding domain in its extracellular region, one transmembrane domain, and a tyrosine kinase-containing domain in its cytosolic region. EGFR is encoded by the gene mapped to human chromosome 7p11.2.

Application

EGFR Active human has been used in:
  • photo-cross-linking assays
  • StavroX cross-linking site identification
  • in vitro kinase assay

Biochem/physiol Actions

Epidermal growth factor receptor (EGFR) functions as a receptor for EGF-family of proteins, which are peptide growth factors. EGFR and ligand play a crucial role early embryonic development and in the renewal of stem cells in tissues such as the gut, liver and skin. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 10 mM glutathione and 3 mM DTT.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Other Notes

One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Tyr substrate per minute at pH 7.4 and 30°C.

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EGFR Active human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP0239

EGFR Active human

EGFR (T790M L858R) Active human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP0242

EGFR (T790M L858R) Active human

EGFR (L861Q), active, GST tagged human PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5325

EGFR (L861Q), active, GST tagged human

Anti-Epidermal Growth Factor (EGF) Receptor, Mouse monoclonal clone 29.1, purified from hybridoma cell culture

Sigma-Aldrich

SAB4200809

Anti-Epidermal Growth Factor (EGF) Receptor, Mouse monoclonal

description

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

description

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

description

PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

description

clone 29.1, purified from hybridoma cell culture

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

biological source

human

biological source

human

biological source

human

biological source

mouse

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

-

concentration

>0.02 mg/mL

concentration

>0.02 mg/mL

concentration

-

concentration

~1 mg/mL

mol wt

87.3 kDa

mol wt

88 kDa

mol wt

~89 kDa

mol wt

~170 kDa

form

aqueous solution

form

aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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