SRP0701
TAU-441 (1-421) Protein
recombinant
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| Size/SKU | Availability | Price |
|---|---|---|
50 μg | Usually ships in 2 weeks. | $513.00 |
About This Item
NACRES:
NA.77
UNSPSC Code:
12352202
Form:
frozen liquid
Assay:
70-95% (SDS-PAGE)
Recombinant:
expressed in E. coli
Mol wt:
~60 kDa
$513.00
Usually ships in 2 weeks.
recombinant
expressed in E. coli
assay
70-95% (SDS-PAGE)
form
frozen liquid
mol wt
~60 kDa
concentration
0.2 μg/μL
accession no.
P10636-8
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MAPT(4137)
Application
Useful for kinase assay and Western blot.
Biochem/physiol Actions
Recombinant human tag-free Tau-441 (1-421) was expressed in E. coli cells. Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).
Preparation Note
Formulated in 50mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
Store in aliquots at -70°C. Avoid freeze/thaw cycles.
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This Item | |||
|---|---|---|---|
| description recombinant | description recombinant | description recombinant | description recombinant |
| assay 70-95% (SDS-PAGE) | assay 70-95% (SDS-PAGE) | assay 70-95% (SDS-PAGE) | assay 70-95% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| concentration 0.2 μg/μL | concentration 0.2 μg/μL | concentration 0.2 μg/μL | concentration 0.2 μg/μL |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
| mol wt ~60 kDa | mol wt ~15 kDa | mol wt ~39 kDa | mol wt ~64-70 kDa |
| Gene Information human ... MAPT(4137) | Gene Information human ... MAPT(4137) | Gene Information human ... MAPT(4137) | Gene Information human ... MAPT(4137) |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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