SRP0702
SORAFENIB
recombinant
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Usually ships in 2 weeks. | $80.80 |
About This Item
NACRES:
NA.77
UNSPSC Code:
12352202
Assay:
>95% (TLC)
Form:
lyophilized powder
assay
>95% (TLC)
form
lyophilized powder
mol wt
~464.8
shipped in
ambient
storage temp.
−20°C
Application
Clinically useful anticancer agent.
Biochem/physiol Actions
Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-beta (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM) (1). Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms (2). Inhibits activation of MAPK pathway and ERK phosphorylation (3). Induces caspase-independent apoptosis in melanoma cells (4).
Preparation Note
Formulated as a lyophilized powder. May be dissolved in DMSO (200 mg/mL) or Ethanol (3 mg/mL).
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
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This Item | |||
|---|---|---|---|
| description recombinant | description European Pharmacopoeia (EP) Reference Standard | description ≥98% (HPLC) | description Pharmaceutical Analytical Impurity (PAI) |
| form lyophilized powder | form - | form powder | form powder |
| assay >95% (TLC) | assay - | assay ≥98% (HPLC) | assay - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| shipped in ambient | shipped in - | shipped in - | shipped in - |
| mol wt ~464.8 | mol wt - | mol wt - | mol wt - |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 1B - STOT RE 1
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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