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SRP2131

LXR, α, ligand binding domain, GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

LXR-a, LXRA, RLD-1

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10 μg
Usually ships in 2 weeks.
$435.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352202

$435.00


Usually ships in 2 weeks.

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biological source

human

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~53.3 kDa

packaging

pkg of 10 μg

concentration

500 μg/mL

color

clear colorless

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NR1H3(10062)

Biochem/physiol Actions

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. LXRα is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRβ expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRα is thought to play a major role in the control of cholesterol catabolism by stimulating the expression of cholesterol 7-α-hydroxylase (CYP7A1), the rate limiting enzyme of bile acid synthesis.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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SRP2138SRP2141SRP2125
description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

Gene Information

human ... NR1H3(10062)

Gene Information

human ... NR1H2(7376)

Gene Information

human ... RARA(5914)

Gene Information

human ... RXRA(6256)


Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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