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SRP2135

PPARα isotype, ligand binding domain, GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

MGC2237, MGC2452, NR1C1, PPAR, PPARalpha, hPPAR

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10 μg
Usually ships in 2 weeks.
$440.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
≥80% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~60.2 kDa

$440.00

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biological source

human

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~60.2 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

color

clear colorless

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PPARA(5465)

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9- cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPARα is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPARγ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. PPARβ is found in many tissues but the highest expression is in the gut, kidney and heart. The target genes of PPARα are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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PPARα isotype, ligand binding domain, GST tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

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SRP2135

PPARα isotype, ligand binding domain, GST tagged human

PPAR, α human recombinant, expressed in E. coli, ≥75% (SDS-PAGE)

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SRP2043

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PPARα, ligand binding domain (170-468) human

LXR, α, ligand binding domain, GST tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

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SRP2131

LXR, α, ligand binding domain, GST tagged human

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥75% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

mol wt

~60.2 kDa

mol wt

~54 kDa

mol wt

~39.4 kDa

mol wt

~53.3 kDa

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

Gene Information

human ... PPARA(5465)

Gene Information

human ... PPARA(5465)

Gene Information

human ... PPARA(5465)

Gene Information

human ... NR1H3(10062)

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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