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SRP2153

HCV-NS4A/NS3-1a Protease, strain H77 from hepatitis C virus

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonym(s):

Hepatitis C virus NS3 protease, NS3, NS4ANS3 complex, pfam02907

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10 μg
Usually ships in 2 weeks.
$576.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352204
Biological source:
hepatitis C virus
Recombinant:
expressed in E. coli
Assay:
≥80% (SDS-PAGE)
Form:
frozen liquid
Mol wt:
~22.7 kDa

$576.00

Usually ships in 2 weeks.
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biological source

hepatitis C virus

recombinant

expressed in E. coli

assay

≥80% (SDS-PAGE)

form

frozen liquid

mol wt

~22.7 kDa

packaging

pkg of 10 μg

concentration

750 μg/mL

color

colorless to clear

NCBI accession no.

AF009606

shipped in

dry ice

storage temp.

−70°C

Gene Information

hepatitis C virus ... HCVgp1(951475)

Biochem/physiol Actions

Persistent infection with hepatitis C virus (HCV) is a common cause of chronic liver disease, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV is an enveloped, single-stranded RNA virus with a 9.6-kb positive-polarity genome, which encodes a polyprotein precursor of about 3,000 amino acids. The HCV polyprotein is proteolytically processed by cellular and HCV proteases into at least 10 distinct products. NS3 serine protease and helicase as well as NS5B RNA-dependent RNA polymerase are believed to be components of a replication complex responsible for viral RNA replication and have been shown to be essential for the HCV replication in chimpanzees. These HCV enzymes have been the major targets for the development of HCV-specific therapeutics during the past decade.The HCV NS3/4A protease is responsible for cleavage at four sites within the HCV polyprotein to generate the N termini of the NS4A, NS4B, NS5A, and NS5B proteins. It has been shown that the central region (amino acids 21-30) of the 54-residue NS4A protein is essential and sufficient for the enhancement of proteolytic activity of the NS3 serine protease. In recent phase I trials, a 2-3-log reduction of HCV viral load was observed after a 2-day treatment with a serine protease inhibitor, which provided the first proof-of-concept evidence that HCV NS3/4A protease inhibitors could be a new therapeutic option for hepatitis C patients.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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This Item
SRP2151SRP2152H7410
HCV-NS4A/NS3-1a Protease, strain H77 from hepatitis C virus recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP2153

HCV-NS4A/NS3-1a Protease, strain H77 from hepatitis C virus

HCV-NS4A/NS3-1b Protease, Histag, strain HC-J4 from hepatitis C virus recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP2151

HCV-NS4A/NS3-1b Protease, Histag, strain HC-J4 from hepatitis C virus

HIV Protease, His tagged,recombinant from HIV-1 recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Sigma-Aldrich

SRP2152

HIV Protease, His tagged,recombinant from HIV-1

HBV core δ antigen (HBcAg) human ~1 mg protein/mL, 95% (SDS-PAGE), recombinant, expressed in E. coli, clone HBV 320

Sigma-Aldrich

H7410

HBV core δ antigen (HBcAg) human

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

description

~1 mg protein/mL, 95% (SDS-PAGE), recombinant, expressed in E. coli, clone HBV 320

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

95% (SDS-PAGE)

biological source

hepatitis C virus

biological source

hepatitis C virus

biological source

human immunodeficiency virus 1

biological source

-

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

concentration

750 μg/mL

concentration

500 μg/mL

concentration

200 μg/mL

concentration

~1 mg protein/mL

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

-

Gene Information

hepatitis C virus ... HCVgp1(951475)

Gene Information

hepatitis C virus ... HCVgp1(951475)

Gene Information

-

Gene Information

hepatitis B virus ... HBVgp4(944568)
human ... HBVgp4(944568)

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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