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SRP3010

BCMA human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

B-Cell Maturation Antigen, BCM, TNFRSF17

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20 μg
Usually ships in 2 weeks.
$408.00

About This Item

NACRES:
NA.32
UNSPSC Code:
12352202

$408.00

Usually ships in 2 weeks.
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biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

mol wt

5.3 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TNFRSF17(608)

General description

B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17(TNFRSF17), a member of the tumor necrosis factor (TNF) receptor superfamily, binds to B-cell–activating factor (BAFF) and a proliferation-inducing ligand (APRIL). BCMA is expressed on mature B-cells and other B-cell lines. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid cytoplasmic domain. Recombinant soluble human BCMA is a 50 amino acid polypeptide (5.3kDa) comprising the TNFR homologous region of the BCMA protein.

Biochem/physiol Actions

B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17 (TNFRSF17) plays an important role in B cell development, function and regulation. BCMA also has the capability to activate nuclear factor-κB (NF-κB), janus kinase (JNK) and mitogen activated protein kinases (MAPKs). The protein is expressed in certain cancers like glioblastoma, chronic lymphocytic leukemia, Hodgkin lymphoma and multiple myeloma. It has a role in the maintenance of survival of long-lived plasma cells in bone marrow.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C

Other Notes

AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA

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This Item
PRS2397WH0000608M1SAB1403600
BCMA human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3010

BCMA human

Anti-BCMA antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

PRS2397

Anti-BCMA antibody produced in rabbit

Monoclonal Anti-TNFRSF17 antibody produced in mouse clone 1F10, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

WH0000608M1

Monoclonal Anti-TNFRSF17 antibody produced in mouse

Monoclonal Anti-TNFRSF17 antibody produced in mouse clone 3H6, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1403600

Monoclonal Anti-TNFRSF17 antibody produced in mouse

description

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

description

affinity isolated antibody, buffered aqueous solution

description

clone 1F10, purified immunoglobulin, buffered aqueous solution

description

clone 3H6, purified immunoglobulin, buffered aqueous solution

technique(s)

cell culture | mammalian: suitable

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable, immunofluorescence: suitable

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

technique(s)

western blot: 1-5 μg/mL, indirect ELISA: suitable, capture ELISA: suitable

biological source

human

biological source

rabbit

biological source

mouse

biological source

mouse

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

assay

≥98% (SDS-PAGE), ≥98% (HPLC)

assay

-

assay

-

assay

-

form

lyophilized

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

Gene Information

human ... TNFRSF17(608)

Gene Information

human ... TNFRSF17(608)

Gene Information

human ... TNFRSF17(608)

Gene Information

human ... TNFRSF17(608)

Storage Class

11 - Combustible Solids

WGK

WGK 3

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