The international unit value for Human IFN-gamma SRP3058 is 1.94 IU/ng of protein.
SRP3058
IFN-γ human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), suitable for cell culture
Synonym(s):
Immune Interferon, MAF, T cell interferon, type II interferon
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| Size/SKU | Availability | Price |
|---|---|---|
100 μg | Usually ships in 2 weeks. | $250.00 |
About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
$250.00
Usually ships in 2 weeks.
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
≤0.75 ng/mL ED50
mol wt
16.9 kDa
packaging
pkg of 100 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IFNG(3458)
General description
IFN-γ (interferon γ) is an acid-labile glycosylated interferon produced by CD4 and CD8 T lymphocytes as well as activated NK (natural killer) cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC (major histocompatibility complex) proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. The gene is mapped to human chromosome 12q15. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7kDa protein containing 143 amino acid residues.
Application
IFN-γ (interferon γ)-human has been used for the generation of inflammatory M1 cells from human monocytic cell line, THP1.
Biochem/physiol Actions
IFN-γ (interferon γ) signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. It can suppress the generation of anti-inflammatory cytokines and enhance the secretion of proinflammatory cytokines. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK (natural killer) cells and neutrophils. It is responsible for tumor rejection and is capable of killing tumor cells by autophagy or apoptosis. IFN-γ is also involved in Hepatitis E virus disease pathogenesis.
Physical form
Lyophilized from a 0.2 μm filtered solution containing 20 mM sodium phosphate, 2% trehalose, 4% mannitol, 0.1% Tween 80, at pH 6.5 with a protein concentration of 0.5 mg/mL.
Preparation Note
Sterile water at 0.1 mg/mLCentrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.
Other Notes
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
1 of 1
This Item | |||
|---|---|---|---|
| description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), suitable for cell culture | description The Interferon-g protein (or IFN-gamma protein) is a lymphoid factor which possesses potent anti-viral activity. | description recombinant, expressed in HEK 293 cells, MS Protein Standard | description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
| recombinant expressed in E. coli | recombinant - | recombinant expressed in HEK 293 cells | recombinant expressed in E. coli |
| biological source human | biological source human | biological source human | biological source human |
| assay ≥98% (SDS-PAGE) | assay >98% (SDS-PAGE and HPLC) | assay ≥98% (SDS-PAGE) | assay ≥98% (HPLC), ≥98% (SDS-PAGE) |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) mass spectrometry (MS): suitable | technique(s) cell culture | mammalian: suitable |
| form lyophilized | form - | form lyophilized powder | form lyophilized |
| storage temp. −20°C | storage temp. -10 to -25°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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