Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

SRP3296

WNT-7A human

recombinant, expressed in HEK 293 cells, ≥80% (SDS-PAGE), ≥80% (HPLC)

Synonym(s):

Human WNT-7A, Recombinant WNT-7A, WNT-7A Signaling Molecule

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
15 μg
Usually ships in 2 weeks.
$390.00
$331.50

About This Item

NACRES:
NA.32
UNSPSC Code:
12352202

$331.50

List Price$390.00Save 15%
Web-Only Promotion
Usually ships in 2 weeks.
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥80% (HPLC), ≥80% (SDS-PAGE)

form

lyophilized

potency

40-60 ng/mL ED50

mol wt

35.5 kDa

packaging

pkg of 15 μg

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

O00755

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... WNT7A(7476)

General description

Wnt-7a is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

Biochem/physiol Actions

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ≤0.2 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
GF175GF170MABD136
WNT-7A human recombinant, expressed in HEK 293 cells, &#8805;80% (SDS-PAGE), &#8805;80% (HPLC)

Sigma-Aldrich

SRP3296

WNT-7A human

WNT-1, Human Recombinant

Sigma-Aldrich

GF175

WNT-1, Human Recombinant

DKK-1 Protein, Human Recombinant The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 &amp; a related protein, Soggy.

Sigma-Aldrich

GF170

DKK-1 Protein, Human Recombinant

Anti-Wnt-5a Antibody, clone 6F2 ascites fluid, clone 6F2, from mouse

Sigma-Aldrich

MABD136

Anti-Wnt-5a Antibody, clone 6F2

description

recombinant, expressed in HEK 293 cells, ≥80% (SDS-PAGE), ≥80% (HPLC)

description

-

description

The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.

description

ascites fluid, clone 6F2, from mouse

assay

≥80% (HPLC), ≥80% (SDS-PAGE)

assay

>98% (SDS-PAGE and HPLC)

assay

>97% (SDS-PAGE and HPLC)

assay

-

recombinant

expressed in HEK 293 cells

recombinant

-

recombinant

-

recombinant

-

biological source

human

biological source

-

biological source

-

biological source

mouse

form

lyophilized

form

-

form

-

form

-

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

-

storage temp.

-

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters