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T182

Tyrphostin A9

solid

Synonym(s):

Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

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Size/SKUAvailabilityPrice
5 mg
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$128.00
$133.00
25 mg
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$323.00

About This Item

Empirical Formula (Hill Notation):
C18H22N2O
CAS Number:
Molecular Weight:
282.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$133.00

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biological source

synthetic (organic)

Quality Segment

assay

≥98% (HPLC)

form

solid

color

yellow

mp

139-140 °C

solubility

ethanol: 20 mg/mL, DMSO: <25 mg/mL, H2O: insoluble

SMILES string

CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C

InChI

1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

InChI key

MZOPWQKISXCCTP-UHFFFAOYSA-N

Application

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Biochem/physiol Actions

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

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This Item
T7040T7665T5443
description

solid

description

≥98%

description

≥98%

description

≥92.5%

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98%

assay

≥98%

assay

≥92.5%

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

solubility

DMSO: <25 mg/mL, ethanol: 20 mg/mL, H2O: insoluble

solubility

chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble

solubility

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

solubility

DMSO: soluble, methanol: soluble

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

-

mp

139-140 °C

mp

113-116 °C (lit.)

mp

-

mp

-


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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