T200
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
≥97% (HPLC), solid
Synonyme(s) :
TPMPA hydrate
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| À vous/Référence | Disponibilité | Prix |
|---|---|---|
10 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 436,00 $ |
50 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 1 220,00 $ |
A propos de cet article
Formule empirique (notation de Hill) :
C6H12NO2P · xH2O
Numéro CAS:
Poids moléculaire :
161.14 (anhydrous basis)
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
436,00 $
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assay
≥97% (HPLC)
form
solid
color
white to off-white
solubility
H2O: 16 mg/mL, DMSO: insoluble
SMILES string
[H]O[H].CP([O-])(=O)C1=CC[NH2+]CC1
InChI
1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2
InChI key
GXVWAQPRAQORGS-UHFFFAOYSA-N
Application
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells.[1]
Biochem/physiol Actions
TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) hydrate is soluble in water at 16 mg/ml, but is insoluble in DMSO.
Legal Information
Sold in the USA under exclusive license from the University of California.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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