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T2057

Trequinsin hydrochloride

≥98%

Synonym(s):

HL 725

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Size/SKUAvailabilityPrice
10 mg
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$397.00

About This Item

Empirical Formula (Hill Notation):
C24H27N3O3 · HCl
CAS Number:
Molecular Weight:
441.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥98%
Form:
powder

$397.00


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Quality Segment

assay

≥98%

form

powder

SMILES string

Cl[H].COc1cc2CCN3C(=O)N(C)C(\C=C3c2cc1OC)=N\c4c(C)cc(C)cc4C

InChI

1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;

InChI key

DTCZZBVPTHVXFA-OSMRDGEFSA-N

Gene Information

Application

Trequinsin has been used as a PDE3 inhibitor in rat juxtaglomerular cells. This study reported that trequinsin can enhance cellular cAMP content, forskolin-induced cAMP synthesis, and renin release in cells.

Biochem/physiol Actions

Phosphodiesterase III inhibitor.
Trequinsin is a strong antihypertensive agent that has a hemodynamic profile similar to that of arteriolar dilators. Trequinsin can block platelet aggregation and also inhibit tissue factor expression in human endothelial cells,.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
382425I1507I2643
description

≥98%

description

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro.

description

≥95% (HPLC), semisynthetic, powder, non-sterile

description

recombinant, expressed in yeast (proprietary host)

assay

≥98%

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

Gene Information

human ... PDE3A(5139), PDE3B(5140)

Gene Information

-

Gene Information

human ... INS(3630)

Gene Information

human ... INS(3630)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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