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Monoclonal Anti-Tenascin antibody produced in mouse

Name: Monoclonal Anti-Tenascin antibody produced in mouse
Brand: SIGMA
Price: 507 USD
Availability: InStock

clone BC-24, ascites fluid

Synonym(s):

Anti-Tenascin-N

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromMILWAUKEE	$507.00
0.2 mL	Available to ship TODAYfromMILWAUKEE	$727.00 $617.95
0.5 mL	Available to ship TODAYfromMILWAUKEE	$1,140.00 $969.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162876

Conjugate:

unconjugated

Clone:

BC-24, monoclonal

Application:

ARR, ELISA (i), ICC, IHC (f), IHC (p), RIA, WB

Citations:

$507.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

BC-24, monoclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:4,000 using protease-digested sections of adult human tissue., immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable, microarray: suitable, radioimmunoassay: suitable, western blot: suitable

isotype

IgG1

UniProt accession no.

Q9UQP3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNN(63923)

Description

General description

Monoclonal Anti-Human Tenascin (mouse IgG1 isotype) is derived from the BC-24 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Tenascin (TN) is a high molecular weight, multifunctional, extracellular matrix glycoprotein, expressed in association with mesenchymal-epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. Human TN has 3 subunits of 190, 200 and 220 kD. TN has been independently discovered in a variety of species and tissue types, often in the basement membrane or intercellular spaces. The expression of TN is associated with development and growth, both normal and pathological, with restricted distribution in normal adult tissue. It is synthesized by fibroblasts, chondroblasts, osteocytes, smooth muscle cells and glial cells. Human and chicken TN contain an RGD sequence which may function in cell adhesion and it seems likely that TN mediates cell attachment through an RGD-dependent integrin receptor. Mouse TN does not contain an RGD sequence in the third type III repeat implicated in cell attachment, or in any other positions.

Immunogen

human tenascin.

Application

Monoclonal Anti-Tenascin antibody produced in mouse has been used for immunohistochemistry.

Mouse monoclonal clone BC-24 anti-Tenascin antibody is an essential tool for the localization, identification and studies on the role of tenascin in epithelial-mesenchymal and neuronal-glial interactions.

Biochem/physiol Actions

Tenascin (TN) is up-regulated by epithelial transforming growth factor β (TGF-β) in mesenchyme. TN in the stroma of cancerous tissue contributes to tumorigenesis and progression of metastasis. High molecular weight TN isoform, a stromal marker of breast cancer, over-expresses implicating cell proliferation and invasion. TN has a potential role in tissue restoration. Intracytoplasmic TN immunoreactivity has been detected in malignant melanomas and in lung carcinomas. TN expression, when reacted with monoclonal antibody, determines its localization in tumor cells and its association with epithelial-mesenchymal and neuronal-glial cell interactions.

The antibody recognizes an epitope within the N-terminal EGF-like (EGF-L) sequence of the molecule. It recognizes all human tenascin isoforms.

Physical form

This product is supplied as ascites fluid containing 15 mM sodium azide

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200782	C5176	C2931
Sigma-Aldrich T2551 Monoclonal Anti-Tenascin antibody produced in mouse	Sigma-Aldrich SAB4200782 Anti-Tenascin antibody, Mouse monoclonal	Sigma-Aldrich C5176 Monoclonal Anti-Cytokeratin Peptide 4 antibody produced in mouse	Sigma-Aldrich C2931 Monoclonal Anti-Cytokeratin, pan antibody produced in mouse
description clone BC-24, ascites fluid	description clone BC-24, purified from hybridoma cell culture	description clone 6B10, ascites fluid	description clone C-11, ascites fluid
antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form ascites fluid
clone BC-24, monoclonal	clone BC-24, monoclonal	clone 6B10, monoclonal	clone C-11, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human	species reactivity human	species reactivity rabbit, feline, hamster, goat, guinea pig, human, canine, sheep	species reactivity bovine, mouse, frog, human, kangaroo rat, rat
Gene Information human ... TNN(63923)	Gene Information human ... TNC(3371)	Gene Information human ... KRT4(3851)	Gene Information bovine ... Krt1(100301161) human ... KRT1(3848), KRT13(3858), KRT13(3858), KRT18(3875), KRT18(3875), KRT4(3851), KRT4(3851), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856) mouse ... Krt1(16678), Krt10(16661), Krt10(16661), Krt13(16663), Krt13(16663), Krt18(16668), Krt18(16668), Krt4(16682), Krt4(16682), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691) rat ... Krt1(300250), Krt1-18(706059), Krt1-18(706059), Krt10(450225), Krt10(450225), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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