Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J. Pharmacol. Exp. Ther., 322, 709-720 (2007).
T3077
TRO 19622
≥98% (HPLC), solid
Synonym(s):
Cholest-4-en-3-one, oxime, NSC 21311, Olesoxime
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $164.00 $170.00 |
About This Item
Empirical Formula (Hill Notation):
C27H45NO
CAS Number:
Molecular Weight:
399.65
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
InChI
1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
InChI key
QNTASHOAVRSLMD-SGWCAAJKSA-N
Application
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Biochem/physiol Actions
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).
Preparation Note
TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description targeting mouse Tro | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form solid | form lyophilized powder | form buffered aqueous glycerol solution | form buffered aqueous glycerol solution |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >10 mg/mL | solubility - | solubility - | solubility - |
| color white | color - | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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What is the structure of TRO 19622, Product T3077?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solubility of TRO 19622, Product T3077?
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This compound is soluble in DMSO (> 10mg/ml).
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How does TRO 19622, Product T3077 work?
1 answer-
TRO 19622 interacts with the mitochondrial permeability transition pore (mPTP). By interacting with protein components of the mPTP, it prevents the release of apoptotic factors and therefore protects the neuron. This mechanism of action may lead to a general neuroprotective activity. Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 322, 709-720, (2007)
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