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Thiolutin

Name: Thiolutin
Brand: SIGMA
Price: 387.6 USD
Availability: InStock

From Streptomyces luteosporeus, ≥95% (HPLC), baterial RNA polymerase inhibitor, solid

Synonym(s):

Farcinicin, N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl), Propiopyvothine

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1 mg	Available to ship TODAYfromMILWAUKEE	$456.00 $387.60

About This Item

Empirical Formula (Hill Notation):

C₈H₈N₂O₂S₂

CAS Number:

87-11-6

Molecular Weight:

228.29

UNSPSC Code:

12352105

PubChem Substance ID:

329826766

NACRES:

NA.77

MDL number:

MFCD07370147

Assay:

≥95% (HPLC)

Form:

solid

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Properties

Product Name

Thiolutin, from Streptomyces luteosporeus, ≥95% (HPLC)

biological source

Streptomyces luteosporeus

Quality Segment

200

assay

≥95% (HPLC)

form

solid

solubility

DMSO: 0.90 - 1.10 mg/ml, clear, yellow

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCC(=O)NC1=C2SSC=C2N(C)C1=O

InChI

1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)

InChI key

UGZYFXMSMFMTSM-UHFFFAOYSA-N

Description

Application

Thiolutin has been used as a polymerase II inhibitor:

to study its effects on yeast cells to calculate transcript half-life
to study its effects on transcription during germination in budding yeast
to study its effects on cell adhesion in zebrafish

Biochem/physiol Actions

Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

Preparation Note

Thiolutin dissolves in DMSO at 0.90 - 1.10 mg/ml to yield a clear, yellow solution.

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This Item	SML2851	SML2779	SML0833
Sigma-Aldrich T3450 Thiolutin	Sigma-Aldrich SML2851 Galunisertib	Sigma-Aldrich SML2779 Tanaproget	Sigma-Aldrich SML0833 HLY78
description from Streptomyces luteosporeus, ≥95% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)
form solid	form powder	form powder	form powder
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 0.90 - 1.10 mg/ml, clear, yellow	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)
shipped in wet ice	shipped in -	shipped in -	shipped in -

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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