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T3694

Tetanus toxin C fragment

from Clostridium tetani, neurotoxin

Synonym(s):

TTC

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10 μg

Available to ship onSeptember 03, 2026fromMILWAUKEE

$927.00
$787.95

About This Item

UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00166041

$787.95

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Available to ship onSeptember 03, 2026Details

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Product Name

Tetanus toxin C fragment from Clostridium tetani,

mol wt

apparent mol wt 47 kDa

Quality Segment

200

color

white

solubility

H2O: soluble

storage temp.

2-8°C

General description

Tetanus toxin C fragment (TTC) is a non-toxic peptide, which is transported from peripheral axons into spinal motoneurons. It provides protection for motoneurons (MN) in the spinal cord in vivo. TTC regulates membrane binding, internalization and retrograde transport within MN. It initiates neurotrophin-regulated signaling pathways in a Trk receptor-dependent manner. TTC has neuroprotective property in primary cerebellar granule cell culture.

Application

The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin.
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.

Biochem/physiol Actions

Tetanus toxin is a neurotoxin that comprises of a heavy and a light chain linked by disulfide bridges. This neurotoxin enters the cytoplasm and releases the light chain component that subsequently inhibits the release of neurotransmitters2. Studies have reported that the fragment C of tetanus toxin retains most of the determinants that interact with thyroid membranes, gangliosides and neural membranes3.

Preparation Note

Each vial, when reconstituted with 50 μl of sterile distilled water, contains 10 μg of tetanus toxin C-fragment in 0.01 M sodium phosphate, pH 7.5. To aid recovery, 0.1% albumin may be added.

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Tetanus toxin C fragment from Clostridium tetani

Sigma-Aldrich

T3694

Tetanus toxin C fragment from Clostridium tetani

Tetanus toxin from Clostridium tetani

Sigma-Aldrich

T3194

Tetanus toxin from Clostridium tetani

Tetanus Toxoid, Clostridium tetani This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.

Sigma-Aldrich

582231

Tetanus Toxoid, Clostridium tetani

Tetanus Toxin, Clostridium tetani Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

Sigma-Aldrich

582243

Tetanus Toxin, Clostridium tetani

description

-

description

-

description

This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.

description

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mol wt

apparent mol wt 47 kDa

mol wt

150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond)

mol wt

-

mol wt

-

solubility

H2O: soluble

solubility

H2O: soluble

solubility

soluble (Reconstitute in 50 µl of sterile distilled H2O)

solubility

soluble (Please refer to the vial label for lot-specific reconstitution volume.)

color

white

color

-

color

-

color

-

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1

target_organs

Central nervous system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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