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T4202

TRKA (440-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

DKFZp781l14186, MTC, NTRK1, TRK1, p140-TrKA

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Size/SKUAvailabilityPrice
10 μg
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$432.00

About This Item

CAS Number:
152787-58-1
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
19-25 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells

$432.00

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biological source

human

Quality Segment

200

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

19-25 nmol/min·mg

mol wt

~66 kDa

technique(s)

activity assay: suitable

UniProt accession no.

P04629

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NTRK1(4914)

Application

TRKA (440-end), active, GST tagged human was used to study functional NGF signal transduction.

Biochem/physiol Actions

TRKA (440-end), active, GST tagged human is a 140 kD membrane-spanning protein tyrosine kinase that belongs to proto-oncogene family. TRKA facilitates the regulation of cell differentiation and survival via activating SHC1 and FRS2 which in turn activates a GRB2-Ras-MAPK cascade. It also plays a pivotal role in controlling NF-κ-B activation as well as transcription of genes involved in cell survival via PLCG1.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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TRKA (440-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

T4202

TRKA (440-end), active, GST tagged human

Anti-TrkA Antibody, clone MNAC13

Sigma-Aldrich

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Anti-TRK A antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

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Anti-TRK A antibody produced in rabbit

TRKB (455-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

T2080

TRKB (455-end), active, GST tagged human

description

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

description

-

description

affinity isolated antibody

description

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Gene Information

human ... NTRK1(4914)

Gene Information

human ... NTRK1(4914)

Gene Information

human ... NTRK1(4914)

Gene Information

human ... NTRK2(4915)

assay

≥70% (SDS-PAGE)

assay

-

assay

-

assay

≥70% (SDS-PAGE)

technique(s)

activity assay: suitable

technique(s)

ELISA: suitable, neutralization: suitable

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100

technique(s)

-

biological source

human

biological source

mouse

biological source

rabbit

biological source

-

specific activity

19-25 nmol/min·mg

specific activity

-

specific activity

-

specific activity

63-85 nmol/min·mg

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

recombinant

-

recombinant

expressed in baculovirus infected Sf9 cells

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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