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T4626

Nα-p-Tosyl-L-arginine methyl ester hydrochloride

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

TAME hydrochloride

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About This Item

Linear Formula:
H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl
CAS Number:
Molecular Weight:
378.87
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352103
EC Number:
217-235-1
MDL number:
Beilstein/REAXYS Number:
3922357
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Product Name

Nα-p-Tosyl-L-arginine methyl ester hydrochloride,

assay

≥98% (TLC)

Quality Segment

form

powder

technique(s)

ligand binding assay: suitable

color

white

mp

145-147 (lit.)

storage temp.

−20°C

SMILES string

Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1

InChI key

JIQFFACVQXXHMY-YDALLXLXSA-N

General description

Substrate for trypsin, thrombin, plasmin, and other proteases.

Application

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts. It has also been used as a substrate for measuring trypsin activity of pancreatin and human intestinal samples.

Biochem/physiol Actions

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

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This Item
C3647A6262A2010
description

-

description

-

description

-

description

-

form

powder

form

powder

form

powder

form

powder

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98.0% (TLC)

assay

≥98% (TLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

white

color

white to off-white

color

colorless to white

mp

145-147 (lit.)

mp

-

mp

-

mp

256-258 °C (dec.) (lit.)


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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