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ANTI-TAU (MAPT) Antibody

Name: ANTI-TAU (MAPT) Antibody
Brand: SIGMA
Price: 700 USD
Availability: InStock

mouse monoclonal, TAU-2

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$700.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164745

Conjugate:

unconjugated

Clone:

TAU-2, monoclonal

Application:

ARR, IHC (p), WB

Citations:

$700.00

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Properties

Product Name

Monoclonal Anti-τ (Tau) antibody produced in mouse, clone TAU-2, ascites fluid

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

TAU-2, monoclonal

mol wt

antigen 55-62 kDa

contains

15 mM sodium azide

species reactivity

monkey, bovine, chicken, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, microarray: suitable, western blot: 1:1,000 using a fresh total bovine brain extract or an enriched microtubule protein preparation

isotype

IgG1

UniProt accession no.

P10636

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAPT(4137)

Description

General description

Monoclonal Anti- τ (TAU) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. τ (TAU) proteins are a part of microtubule associated proteins (MAPs). They are densely found in neurons and in trace amounts in non-neuronal cells. In brain six isoforms of τ (TAU) proteins are present.

The antibody reacts exclusively with the chemically heterogeneous τ in both the phosphorylated and non-phosphorylated form. The antibody does not react with other MAPs or with tubulin. In immunohistochemical staining, it localizes τ along microtubules in axons, somata, dendrites and astrocytes, and on ribosomes. The antibody may be used for staining of τ in Alzheimer neurofibrillary tangles in sections of human brain tissue.

The best known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is chemically heterogenous, however, limited protolysis has demonstrated that the different eletrophoretic species are closely related. Tau is immunologically distinct from the other MAPs, namely MAP1, MAP2 and MAP5. Localization studies have demonstrated that Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.

Immunogen

bovine microtubule-associated proteins (MAPs)

Application

Monoclonal Anti-τ (Tau) antibody has been used:

in immunohistology
in immunoblotting
in dot blot
in immunohistochemistry

Mouse monoclonal clone TAU-2 anti-Tau antibody maybe used to study microtubule associated proteins (MAP) expression and cytological localization in various tissue and cell lines, under different developmental and environmental circumstances.

Biochem/physiol Actions

Monoclonal Anti- τ (TAU) is phosphatase independent; it will bind Tau proteins in either their phosphorylated or non-phosphorylated forms. It localizes Tau proteins along microtubules in axons, somata, dendrites, astrocytes and on ribosomes (polysomes). The best-known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is immunologically distinct from the other MAPs. Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T9450	T6402	AB9674
Sigma-Aldrich T5530 Monoclonal Anti-τ (Tau) antibody produced in mouse	Sigma-Aldrich T9450 Anti-Tau antibody, Mouse monoclonal	Sigma-Aldrich T6402 Anti-τ (Tau) antibody produced in rabbit	Sigma-Aldrich AB9674 Anti-Tau phospho Serine 199/202 Antibody
description clone TAU-2, ascites fluid	description clone Tau46, purified from hybridoma cell culture	description whole antiserum	description Chemicon^®, from rabbit
antibody form ascites fluid	antibody form purified immunoglobulin	antibody form whole antiserum	antibody form affinity purified immunoglobulin
clone TAU-2, monoclonal	clone Tau46, monoclonal	clone polyclonal	clone polyclonal
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
species reactivity monkey, bovine, chicken, human	species reactivity bovine, rat, human, mouse	species reactivity chicken, rat, mouse	species reactivity human
Gene Information human ... MAPT(4137)	Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)	Gene Information human ... MAPT(4137)	Gene Information human ... MAPT(4137)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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