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T5694

TRAIL human

recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder

Synonym(s):

Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand

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10 μg

Available to ship TODAYfromMILWAUKEE

$653.00
$555.05

About This Item

CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
24 kDa by SDS-PAGE, predicted mol wt ~21 kDa

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biological source

human

Quality Segment

recombinant

expressed in NSO cells

description

N-terminal 6X histidine-tagged extracellular domain

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

24 kDa by SDS-PAGE, predicted mol wt ~21 kDa

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TNFSF10(8743)

Application

TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.

Biochem/physiol Actions

TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Analysis Note

Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.

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T9701R0525SRP8043
description

recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder

description

recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder

description

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

biological source

human

biological source

human

biological source

mouse

biological source

mouse

assay

>97% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

assay

≥98% (SDS-PAGE)

assay

>95% (SDS-PAGE)

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

technique(s)

cell culture | mammalian: suitable

technique(s)

immunofluorescence: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

mol wt

24 kDa by SDS-PAGE, predicted mol wt ~21 kDa

mol wt

19.6 kDa, predicted mol wt ~21 kDa

mol wt

-

mol wt

~34 kDa by SDS-PAGE


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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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