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T6031

DL-Thiorphan

≥98% (TLC), Enkephalinase inhibitor., powder

Synonym(s):

(±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$250.00
25 mg

Available to ship TODAYfromMILWAUKEE

$873.00

About This Item

Empirical Formula (Hill Notation):
C12H15NO3S
CAS Number:
Molecular Weight:
253.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
4872101
Assay:
≥98% (TLC)
Form:
powder

$250.00


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Product Name

DL-Thiorphan, ≥98% (TLC)

Quality Segment

assay

≥98% (TLC)

form

powder

mp

138 °C

solubility

ethanol: soluble 49.00-51.00 mg/mL, clear, colorless

SMILES string

OC(=O)CNC(=O)C(CS)Cc1ccccc1

InChI

1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)

InChI key

LJJKNPQAGWVLDQ-UHFFFAOYSA-N

Gene Information

General description

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Application

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Biochem/physiol Actions

Enkephalinase inhibitor.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

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This Item
C4042E5139
description

≥98% (TLC)

description

≥98% (HPLC), powder

description

≥95% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥95% (TLC)

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

200

solubility

ethanol: soluble 49.00-51.00 mg/mL, clear, colorless

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

-

mp

138 °C

mp

104-108 °C (lit.)

mp

269 °C

Gene Information

human ... ACE(1636), ECE1(1889)
rat ... Ace(24310), Mme(24590)

Gene Information

human ... ACE(1636), AGTR1(185), AGTR2(186), ECE1(1889)
rat ... Ace(24310)

Gene Information

-


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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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