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T6394

Timolol maleate salt

≥98% (TLC), β-adrenoceptor antagonist, powder

Synonym(s):

S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt, Timolol hydrogen maleate

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100 mg

Available to ship TODAYfromMILWAUKEE

$93.30
250 mg

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$205.00
1 g
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$589.00

About This Item

Empirical Formula (Hill Notation):
C13H24N4O3S · C4H4O4
CAS Number:
Molecular Weight:
432.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-111-5
MDL number:
Assay:
≥98% (TLC)
Form:
powder

$93.30


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Product Name

Timolol maleate salt, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)

color

white to off-white

mp

202-203 °C (lit.)

solubility

H2O: soluble, ethanol: soluble

ε (extinction coefficient)

8,700 at 294 nm at 1 M

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2

InChI

1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1

InChI key

WLRMANUAADYWEA-NWASOUNVSA-N

Gene Information

Application

Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.

Biochem/physiol Actions

Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Timolol maleate is soluble in ethanol and water.

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This Item
M110C6848E6888
description

≥98% (TLC), powder

description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

powder, ≥98.0% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble, ethanol: soluble

solubility

H2O: >3 mg/mL, clear (warmed)

solubility

DMSO: 32 mg/mL, H2O: insoluble

solubility

methanol: ≥50 mg/mL, clear, colorless to yellow

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

color

white to off-white

color

white to dark brown

color

white to beige

color

white to off-white


pictograms

Health hazardExclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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