Skip to Content
MilliporeSigma

Skip To

T6394

Timolol maleate salt

≥98% (TLC), β-adrenoceptor antagonist, powder

Synonym(s):

S-(−)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt, Timolol hydrogen maleate

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
100 mg
Check Cart for Availability
$93.30
250 mg
Check Cart for Availability
$205.00
1 g

Estimated to ship onOctober 27, 2026fromMILWAUKEE

$589.00

About This Item

Empirical Formula (Hill Notation):
C13H24N4O3S · C4H4O4
CAS Number:
Molecular Weight:
432.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-111-5
MDL number:
Assay:
≥98% (TLC)
Form:
powder

$93.30


Check Cart for Availability

​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

Timolol maleate salt, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)

color

white to off-white

mp

202-203 °C (lit.)

solubility

H2O: soluble, ethanol: soluble

ε (extinction coefficient)

8,700 at 294 nm at 1 M

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2

InChI

1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1

InChI key

WLRMANUAADYWEA-NWASOUNVSA-N

Gene Information

Application

Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.

Biochem/physiol Actions

Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Timolol maleate is soluble in ethanol and water.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
1667406Y0001270C6848
description

≥98% (TLC), powder

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

≥98% (HPLC), powder

assay

≥98% (TLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

powder

form

-

form

-

form

powder

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

solubility

ethanol: soluble, H2O: soluble

solubility

-

solubility

-

solubility

DMSO: 32 mg/mL, H2O: insoluble

color

white to off-white

color

-

color

-

color

white to beige

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

originator

-

originator

-


Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters