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T6632

Thymidine Phosphorylase, recombinant from Escherichia coli

recombinant, expressed in E. coli, buffered aqueous solution, ≥900 units/mL, 0.2 μm filtered

Synonym(s):

Thymidine:orthophosphate deoxy-D-ribosyltransferase

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Size/SKUAvailabilityPrice
5000 units
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$1,770.00

About This Item

CAS Number:
9030-23-3
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00132426
EC Number:
2.4.2.4 (BRENDA, IUBMB)
Recombinant:
expressed in E. coli
Concentration:
≥900 units/mL

$1,770.00

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Diagnostics Manufacturers should use alternative grade product: SRE0006
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recombinant

expressed in E. coli

Quality Segment

300

sterility

0.2 μm filtered

form

buffered aqueous solution

concentration

≥900 units/mL

UniProt accession no.

P07650

storage temp.

2-8°C

Gene Information

Escherichia coli K12 ... deoA(948901)

General description

Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation.

Application

Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues.

Biochem/physiol Actions

An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway.
An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.

Physical form

Solution in 0.5 M potassium phosphate containing 2 mM uracil, 0.02% sodium azide and bovine serum albumin

Preparation Note

Cloned from E. coli and produced in overexpressing E. coli

Other Notes

One unit will convert 1.0 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per min at pH 7.4 at 25°C.

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T2807SRE0006N2415
Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, buffered aqueous solution, ≥900 units/mL, 0.2 μm filtered

Sigma-Aldrich

T6632

Thymidine Phosphorylase, recombinant from Escherichia coli

Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, buffered aqueous solution, ≥500 units/mL

Sigma-Aldrich

T2807

Thymidine Phosphorylase, recombinant from Escherichia coli

Thymidine Phosphorylase, recombinant from Escherichia coli recombinant, expressed in E. coli, Suitable for manufacturing of diagnostic kits and reagents, buffered aqueous solution, ≥500 units/mL

Sigma-Aldrich

SRE0006

Thymidine Phosphorylase, recombinant from Escherichia coli

Nucleoside Phosphorylase bacterial recombinant, expressed in E. coli, ≥10 units/mg protein

Sigma-Aldrich

N2415

Nucleoside Phosphorylase bacterial

description

recombinant, expressed in E. coli, buffered aqueous solution, ≥900 units/mL, 0.2 μm filtered

description

recombinant, expressed in E. coli, buffered aqueous solution, ≥500 units/mL

description

recombinant, expressed in E. coli, Suitable for manufacturing of diagnostic kits and reagents, buffered aqueous solution, ≥500 units/mL

description

recombinant, expressed in E. coli, ≥10 units/mg protein

Gene Information

Escherichia coli K12 ... deoA(948901)

Gene Information

Escherichia coli K12 ... deoA(948901)

Gene Information

Escherichia coli ... deoA(948901)

Gene Information

Escherichia coli ... deoD(945654)

concentration

≥900 units/mL

concentration

≥500 units/mL

concentration

≥500 units/mL

concentration

-

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

lyophilized powder

UniProt accession no.

P07650

UniProt accession no.

P07650

UniProt accession no.

P07650

UniProt accession no.

P0ABP8

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

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