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TRAM-34

Name: TRAM-34
Brand: SIGMA
Price: 222 USD
Availability: InStock

≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid

Synonym(s):

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

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Size/SKU	Availability	Price
5 mg	Available to ship TODAYfromMILWAUKEE	$222.00
25 mg	Available to ship TODAYfromMILWAUKEE	$697.00

About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₇ClN₂

CAS Number:

289905-88-0

Molecular Weight:

344.84

UNSPSC Code:

12352200

PubChem Substance ID:

329826852

NACRES:

NA.77

MDL number:

MFCD09842562

Assay:

≥98% (HPLC)

Form:

solid

$222.00

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Properties

Product Name

TRAM-34, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: 2 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4

InChI

1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H

InChI key

KBFUQFVFYYBHBT-UHFFFAOYSA-N

Description

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

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This Item	C6617	U3885	I6783
Sigma-Aldrich T6700 TRAM-34	Sigma-Aldrich C6617 CBIQ	Sigma-Aldrich U3885 UK-78282 monohydrochloride	Sigma-Aldrich I6783 Isopimaric Acid
description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥98% (GC), powder
form solid	form solid	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (GC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 2 mg/mL, H₂O: insoluble	solubility DMSO: 15 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 25 mg/mL
color off-white	color off-white	color white to off-white	color white

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302,H413

Precautionary Statements

P264 - P270 - P273 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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