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Anti-phospho-Tau (pSer^199/202) antibody produced in rabbit

Name: Anti-phospho-Tau (pSer<SUP>199/202</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 959 USD
Availability: InStock

affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU

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Size/SKU	Availability	Price
1 vial	Check Cart for Availability	$959.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03455771

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$959.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

rat, mouse, human

technique(s)

microarray: suitable, western blot: suitable

UniProt accession no.

P10636

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer199/pSer202)

Gene Information

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

Description

General description

Tau (τ), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.

Tau proteins are known as microtubule-associated phosphoprotein (MAP) and express mainly in neurons of central nervous system. It has a crucial role in tubulin polymerization and facilitates microtubules assembly and stability. The biological activity of tau proteins depends on degree of its phosphorylation. Anti-phospho-Tau (pSer^199/202) antibody can be used in microarray and western blotting. It can also be used in immunoblotting. Rabbit anti- phospho-Tau (pSer^199/202) antibody reacts specifically with human Tau (pSer^199/202) (45-68 kD).

Immunogen

chemically synthesized phosphopeptide derived from the region of human tau that contains serine¹⁹⁹ and serine²⁰².

Application

Anti-phospho-Tau (pSer199/202) antibody produced in rabbit has been used in:

immunocytochemistry
immunohistochemistry
western blot

Anti-phospho-Tau (pSer^199/202) antibody (diluted 1:1000 in PBS containing 0.3% Triton X-100 and 0.5% BSA) can be used in immunocytochemistry for identification of protein aggregates. It can also be used as primary antibody (diluted 1: 3000) in immunohistochemistry.

Biochem/physiol Actions

Tau (τ) plays an essential role in the assembly and maintenance of microtubule structure. Deletion of tau (τ) results in developmental delay and learning disability. The gene expression is associated with the development of Alzheimer′s disease (AD). Genetic variation in τ gene increases the risk of susceptibility to the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration.

Physical form

Solution in 100 μl Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, 50% glycerol, containing 1.0 mg/ml BSA (IgG, protease free) and 0.05% sodium azide. The amount of antibody is sufficient for 10 immunoblots.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T7569	T7319	T9450
Sigma-Aldrich T6819 Anti-phospho-Tau (pSer^199/202) antibody produced in rabbit	Sigma-Aldrich T7569 Anti-phospho-Tau (pSer²⁶²) antibody produced in rabbit	Sigma-Aldrich T7319 Anti-phospho-Tau (pSer³⁹⁶) antibody produced in rabbit	Sigma-Aldrich T9450 Anti-Tau antibody, Mouse monoclonal
description affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, buffered aqueous glycerol solution	description clone Tau46, purified from hybridoma cell culture
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)	Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)	Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)	Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)
species reactivity rat, mouse, human	species reactivity rat, mouse, human	species reactivity human, mouse, rat	species reactivity bovine, rat, human, mouse

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

320.0 °F - closed cup

flash_point_c

160 °C - closed cup

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