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Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human

Name: Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD02689206

Form:

lyophilized powder

Assay:

>95% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in NSO cells

Mol wt:

52.6 kDa

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Properties

biological source

human

Quality Segment

200

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.004-0.016 mg per mL ED₅₀

mol wt

52.6 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P20333

storage temp.

−20°C

Gene Information

human ... TNFRSF1B(7133)

Description

Application

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function.[1] It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Analysis Note

The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.

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This Item	T7799	H8916	I5403
Sigma-Aldrich T7189 Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human	Sigma-Aldrich T7799 Tumor Necrosis Factor-β human	Sigma-Aldrich H8916 Tumor Necrosis Factor-α human	Sigma-Aldrich I5403 Insulin-Like Growth Factor Binding Protein-2 human
biological source human	biological source human	biological source human	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in NSO cells	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in NSO cells
assay >95% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
form lyophilized powder	form powder	form lyophilized powder	form lyophilized powder
mol wt 52.6 kDa	mol wt protein 18.8 kDa	mol wt 17 kDa (glycosylated), ~17.4 kDa	mol wt ~36 kDa by SDS-PAGE, calculated mol wt ~31 kDa

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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