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T7383

Tetracaine

≥98% (TLC)

Synonym(s):

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

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25 g
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$206.00
100 g
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$612.00

About This Item

Empirical Formula (Hill Notation):
C15H24N2O2
CAS Number:
94-24-6
Molecular Weight:
264.36
NACRES:
NA.32
PubChem Substance ID:
57654695
UNSPSC Code:
12352200
EC Number:
202-316-6
MDL number:
MFCD00053787
Assay:
≥98% (TLC)
Form:
powder

$206.00

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biological source

synthetic (organic)

Quality Segment

assay

≥98% (TLC)

form

powder

technique(s)

toxicology assay: suitable

storage temp.

2-8°C

SMILES string

CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

InChI key

GKCBAIGFKIBETG-UHFFFAOYSA-N

Gene Information

General description

Tetracaine belongs to the amino-ester class and has a pKa of 8.46.

Application

Topical ophthalmic anesthetic; used for spinal anesthesia
Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.
Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.
Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.
Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Preparation Note

250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.

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This Item
1649991PHR3140Y0002117
Tetracaine ≥98% (TLC)

Sigma-Aldrich

T7383

Tetracaine

Tetracaine United States Pharmacopeia (USP) Reference Standard

USP

1649991

Tetracaine

Tetracaine pharmaceutical secondary standard, certified reference material

Supelco

PHR3140

Tetracaine

Tetracaine European Pharmacopoeia (EP) Reference Standard

Y0002117

Tetracaine

description

≥98% (TLC)

description

United States Pharmacopeia (USP) Reference Standard

description

pharmaceutical secondary standard, certified reference material

description

European Pharmacopoeia (EP) Reference Standard

form

powder

form

-

form

-

form

-

assay

≥98% (TLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

technique(s)

toxicology assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

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Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Codes

H301,H317,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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