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T7799

Tumor Necrosis Factor-β human

>95% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture | mammalian: suitable

Synonym(s):

TNF-β

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10 μg

Available to ship TODAYfromMILWAUKEE

$438.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00163958
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
>95% (SDS-PAGE)
Form:
powder
Mol wt:
protein 18.8 kDa
Impurities:
≤1 EU/μg

$438.00

Available to ship TODAYDetails

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Product Name

Tumor Necrosis Factor-β human, TNF-β, recombinant, expressed in E. coli, powder, suitable for cell culture

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

powder

potency

4-20 pg/mL Activity

quality

endotoxin tested

mol wt

protein 18.8 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P01374

storage temp.

−20°C

Gene Information

human ... LTA(4049), TNFSF13B(10673)

Biochem/physiol Actions

Tumor necrosis factor-β (TNF-β), also known as lymphotoxin-α (LT-α) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-β and TNF-α share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-α, TNF-β can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-β (LT-β). Reportedly, LTα1/β2, the predominant heterotrimer, binds and activates only the LT-β receptor, LT-βR. The other heterotrimer, LT-α2/β1 binds and activates TNFR1 and TNFR2 but not LT-βR. TNF-β is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-β, LT-β and TNF-α are tightly linked near each other within the MHC. TNF-β appears to play many of the same biological roles as TNF-α, but the membrane-bound form with LT-β is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-α and TNF-β have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-β are 74% homologous and human and mouse LT-β are 80% homologous.
Tumor necrosis factor-β, also known as lymphotoxin-α (LT-α) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes.

Physical form

lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein

Analysis Note

The biological activity is measured in a cytotoxicity assay using the TNF-suspectible murine L929 cell line in the presence of actinomycin D.

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description

TNF-β, recombinant, expressed in E. coli, powder, suitable for cell culture

description

Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture

description

TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture

description

TGF-β2, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

assay

>95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥97% (electrophoresis)

assay

≥95% (SDS-PAGE)

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in NSO cells

recombinant

expressed in HEK 293 cells

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

biological source

human

biological source

human

biological source

human

biological source

human

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

lyophilized powder

form

powder

form

lyophilized powder

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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