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T7799

Tumor Necrosis Factor-β human

>95% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture | mammalian: suitable

Synonyme(s) :

TNF-β

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À vous/RéférenceDisponibilitéPrix
10 μg
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395,00 €
335,75 €

A propos de cet article

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00163958
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
>95% (SDS-PAGE)
Form:
powder
Mol wt:
protein 18.8 kDa
Impurities:
≤1 EU/μg

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Nom du produit

Tumor Necrosis Factor-β human, TNF-β, recombinant, expressed in E. coli, powder, suitable for cell culture

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

powder

potency

4-20 pg/mL Activity

quality

endotoxin tested

mol wt

protein 18.8 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P01374

storage temp.

−20°C

Gene Information

human ... LTA(4049), TNFSF13B(10673)

Biochem/physiol Actions

Tumor necrosis factor-β (TNF-β), also known as lymphotoxin-α (LT-α) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-β and TNF-α share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-α, TNF-β can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-β (LT-β). Reportedly, LTα1/β2, the predominant heterotrimer, binds and activates only the LT-β receptor, LT-βR. The other heterotrimer, LT-α2/β1 binds and activates TNFR1 and TNFR2 but not LT-βR. TNF-β is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-β, LT-β and TNF-α are tightly linked near each other within the MHC. TNF-β appears to play many of the same biological roles as TNF-α, but the membrane-bound form with LT-β is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-α and TNF-β have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-β are 74% homologous and human and mouse LT-β are 80% homologous.
Tumor necrosis factor-β, also known as lymphotoxin-α (LT-α) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes.

Physical form

lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein

Analysis Note

The biological activity is measured in a cytotoxicity assay using the TNF-suspectible murine L929 cell line in the presence of actinomycin D.

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Cet article
T6674H8916T5944
Tumor Necrosis Factor-β human TNF-β, recombinant, expressed in E. coli, powder, suitable for cell culture

Sigma-Aldrich

T7799

Tumor Necrosis Factor-β human

Facteur de nécrose tumorale-α human TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

Sigma-Aldrich

T6674

Facteur de nécrose tumorale-α human

Facteur de nécrose tumorale-α human Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture

Sigma-Aldrich

H8916

Facteur de nécrose tumorale-α human

Tumor Necrosis Factor-α from rat TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

Sigma-Aldrich

T5944

Tumor Necrosis Factor-α from rat

description

TNF-β, recombinant, expressed in E. coli, powder, suitable for cell culture

description

TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

description

Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture

description

TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

biological source

human

biological source

human

biological source

human

biological source

rat

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

assay

>95% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

lyophilized powder

form

powder

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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