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Anti-Titin antibody, Mouse monoclonal

Name: Anti-Titin antibody, Mouse monoclonal
Brand: SIGMA
Price: 568 USD
Availability: InStock

clone T11, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-Titin antibody produced in mouse, Anti-CMD1G, Anti-CMH9, Anti-CMPD4, Anti-EOMFC, Anti-HMERF, Anti-LGMD2J, Anti-LGMDR10, Anti-MYLK5, Anti-SALMY, Anti-TMD

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Size/SKU	Availability	Price
0.2 mL	Check Cart for Availability	$568.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164750

Conjugate:

unconjugated

Clone:

T11, monoclonal

Application:

EM, IF, IHC (f), WB

Citations:

$568.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

T11, monoclonal

contains

15 mM sodium azide

species reactivity

vertebrates, chicken

technique(s)

electron microscopy: suitable, immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1:1,000 using frozen tissue sections of animal skeletal muscle, western blot: suitable

isotype

IgG2b

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

chicken ... TTN(424126)

Description

General description

Monoclonal Anti-Titin (mouse IgG2b isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. It is a flexible, filamentous constituent of striated muscle that is thought to give rise to an elastic filament component underlying the myofibrillar organization.

Titin (TTN), also known as connectin, is encoded by the gene mapped to human chromosome 2q31.2. TTN is a giant elastic protein expressed in striated and smooth muscles of vertebrates. The encoded protein contains up to 300 immunoglobulin-like and fibronectin type-3-like (FN3) domains.

Immunogen

titin/nebulin fraction from chicken breast muscle.

Application

Monoclonal Anti-Titin antibody produced in mouse has been used in following studies.

western blotting
antibody staining
immunofluorescence microscopy
immunohistochemistry

Biochem/physiol Actions

Monoclonal Anti-Titin can be used for study of the elastic filaments within sarcomeric structures. It is also useful as a differentiation marker in the separation of rhabdomyosarcomas from other muscle tumors.

The antibody localizes titin (connectin) in skeletal and heart muscle of a wide variety of species from cold-blooded vertebrates to human. The antibody does not cross-react with nebulin. Likewise, it does not react with smooth muscle, non-muscle tissues, or cultured cells.

Titin (TTN) helps in maintaining sarcomeric structural integrity by interacting with many other myofibrillar and cytoskeletal proteins. Additionally, it is also involved in developing the passive elastic force in muscle. Genetic variations in the gene has been associated with the development of dilated cardiomyopathy (DCM).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T9283	F6140	F0791
Sigma-Aldrich T9030 Anti-Titin antibody, Mouse monoclonal	Sigma-Aldrich T9283 Anti-Tropomyosin (Sarcomeric) antibody, Mouse monoclonal	Sigma-Aldrich F6140 Monoclonal Anti-Fibronectin, Cellular antibody produced in mouse	Sigma-Aldrich F0791 Monoclonal Anti-Fibronectin antibody produced in mouse
description clone T11, purified from hybridoma cell culture	description clone CH1, purified from hybridoma cell culture	description clone FN-3E2, ascites fluid	description clone IST-3, ascites fluid
species reactivity vertebrates, chicken	species reactivity human, chicken, rat	species reactivity mouse, human, chicken	species reactivity goat, canine, human, chicken, sheep, rabbit, bovine
clone T11, monoclonal	clone CH1, monoclonal	clone FN-3E2, monoclonal	clone IST-3, monoclonal
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form ascites fluid
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information chicken ... TTN(424126)	Gene Information chicken ... TPM1(396366) human ... TPM1(7168) rat ... Tpm1(24851)	Gene Information human ... FN1(2335) mouse ... Fn1(14268)	Gene Information human ... FN1(2335)

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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